What the Transfem Guide on The DIY HRT Directory 2.0 Covers

The DIY HRT Directory 2.0 is a harm-reduction resource that publishes a dedicated Transfem Guide for people pursuing feminizing hormone replacement therapy outside formal medical channels. The site states its purpose plainly: HRT is inaccessible for many trans people because of cost, family issues, or other barriers, and the directory is built to teach safer DIY use for those who fall into that category. The Transfem Guide is one of two parallel tracks (the other is the Transmasc Guide), and it sits alongside supporting material on blood testing, injection supplies, and informed consent/telehealth. The site does not sell products or services, and it carries an explicit caution to consult a physician or qualified provider before starting any new health regimen.

What the Transfem Guide is for

The guide is written for transfeminine people who are considering or already managing feminizing HRT without a prescribing clinician. Its framing is harm reduction rather than encouragement: the directory assumes the reader has already decided to pursue DIY HRT and focuses on doing it more safely.

Two boundaries are worth stating up front, because the site states them:

• The directory sells nothing. It is an information host, not a vendor, so any product links you encounter are third-party.
• It disclaims responsibility for what readers do with the information and for the content of external sites it links to.

The site also asks readers to share it with people who need it — but not with transphobes.

Core topics the Transfem Guide addresses

Based on the directory's structure and stated scope, the Transfem Guide covers the practical components of feminizing DIY HRT:

• Hormone basics for a transfem regimen — the estrogen and anti-androgen options typically used in feminizing therapy, and how they are administered.
• Dosing and administration — how the guide frames starting, adjusting, and maintaining a regimen.
• Safety monitoring — what to watch for and how to interpret the results you get.
• Supply sourcing — where to obtain what you need, with the caveat that the directory itself is not a seller.

The directory does not publish pricing, and no payment platforms are referenced, so treat any cost figures you see elsewhere as unverified against this source.

Blood testing: the monitoring layer

The directory treats blood testing as a standalone topic, separate from the two guides. For a transfem regimen, the relevant markers are estrogen (E) and testosterone (T) levels. The Blood Testing section is where the directory explains how to understand those levels — which matters because DIY dosing without lab feedback is guesswork.

If you are managing your own regimen, the practical sequence is:

1. Read the Transfem Guide for the regimen framework.
2. Read the Blood Testing section to understand what E and T levels mean and how to track them.
3. Use the results to inform adjustments, ideally with a clinician's input where you can get it.

Injection supplies and safer use

The directory includes a dedicated page on finding safe injection supplies. This is relevant if your regimen uses injectable estrogen, which is one of the common routes in feminizing HRT. The page's purpose is sourcing — where to get sterile, appropriate supplies — rather than technique, though the Transfem Guide is the place to look for how the guide frames administration.

Informed consent and telehealth as an alternative path

The directory does not present DIY as the only option. It maintains an Informed Consent and Telehealth Guide, which covers the formal route: clinics and services that prescribe HRT under an informed-consent model, and telehealth providers that operate remotely. For readers who can access these, this path offers prescribed hormones and professional monitoring — which is the safer configuration the directory's own caution points toward.

The site's own advice is explicit: always seek the advice of a physician or other qualified healthcare provider with any questions about a medical condition or treatment, and before undertaking a new health care regimen. If you think you may have a medical emergency, contact your doctor or emergency services.

How to use the directory

The directory also lists a contact address for questions or concerns, and maintains a Changelog and Noticeboard for updates.

What the guide does not do

It does not sell hormones or supplies, does not provide individualized medical advice, and does not take responsibility for outcomes. It is a reference and a starting point — not a substitute for a clinician, and not a guarantee of safety. The most defensible way to use it is as a supplement to professional care where that care is available, and as a harm-reduction reference where it is not.