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EnglishWhat Genetic Heart Diseases Does AF-ABLATION Research and Treat?
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AF-ABLATION, the Department of Arrhythmia and Electrophysiology at Policlinico San Donato (Milan area), states that it is a leading center worldwide for ablative therapy and for the study of the omics of Brugada syndrome, long QT syndrome, and other genetic heart diseases. Its site lists substrate ablation of Brugada syndrome as a clinical procedure and maintains dedicated publications and blog sections. The center describes itself as a leading center; no independent ranking or outcome data is provided on the page.
The inherited conditions named on the site
| Condition | How it appears on the AF-ABLATION site | What that means for patients |
|---|---|---|
| Brugada syndrome | Named in the center's description as a core research focus; "Substrate Ablation of Brugada Syndrome" is listed among its electrophysiology procedures | The center both studies the condition and offers an invasive treatment option for it |
| Long QT syndrome | Named alongside Brugada syndrome as a focus of omics study | Evaluation and research interest, rather than a listed ablation procedure |
| Other genetic heart diseases | Referenced generally in the center's description | The site does not enumerate them; specifics need to be confirmed directly with the department |
The site does not publish a full list of inherited conditions, diagnostic criteria, or eligibility rules for each. Treat the table as a map of what the center advertises, not as a complete clinical scope.
What "omics" research means here
Omics refers to large-scale study of a person's genes and molecular profile. In inherited arrhythmias, this kind of work looks for the biological signals that explain why one person with a gene variant develops dangerous rhythms and another does not. AF-ABLATION frames this as the scientific side of its practice, running alongside its ablation work rather than replacing it.
A concrete example of why the distinction matters: a family member found to carry a Brugada-linked variant may want to know what it means for them. Omics research is where such questions are studied; the site does not describe a public genetic counseling or family screening pathway, so that would need to be asked about directly.
Where ablation fits for Brugada syndrome
Most of the department's listed procedures are catheter-based rhythm treatments, and Brugada syndrome is the one genetic condition with a named ablation procedure on the site: substrate ablation of Brugada syndrome. This is an invasive electrophysiology procedure, performed in the department's electrophysiology laboratory, and it sits within a broader menu that includes atrial fibrillation ablation, ventricular tachycardia ablation, and implantable device services.
The site does not state who is a candidate for substrate ablation, how it compares with medication or defibrillators, or what results patients should expect. Those are decisions for the treating electrophysiologist after evaluation.
Following the research output
Two sections are the practical way to track the center's work:
- AF-ablation Publications — the department's research output, including its omics work.
- AF-ablation blog — shorter updates and commentary.
Neither section's contents are reproduced in the available page material, so check both directly for current papers and posts.
Getting a specific answer
For questions about a particular diagnosis, eligibility for substrate ablation, or the scope of genetic evaluation, the site provides a direct route: appointment and information requests by phone at +39 02 36552440, or at the department's address, Piazza Edmondo Malan 2, San Donato M.se – Milano. The site lists no online booking form, pricing, or insurance details, so confirm availability, costs, and referral requirements when you contact the department.