What Types of Oligos and Modifications Does IDT Offer?

Updated

IDT (Integrated DNA Technologies) offers custom DNA oligos, custom RNA oligos, oligo pools, and custom GMP oligos, plus a broad menu of oligo modifications you can attach during synthesis. On the EU site (eu.idtdna.com), these products sit under Products & Services → Oligos & Reagents, and the same catalog is used for ordering. The practical answer depends on what you need: standard primers and probes, long or high-fidelity constructs, pooled libraries, or chemically modified oligos for detection and labeling.

Core oligo categories

Custom DNA oligos

This is the main workhorse category. It includes:

  • DNA Oligos — standard custom DNA synthesis.
  • Ultramer DNA Oligos — a product line for longer or more demanding DNA oligos.
  • Oligo pools — pooled oligo products for high-throughput or library-style applications.
  • SameDay Oligos — a faster-turnaround option.
  • HotPlates Oligos — plate-format oligo delivery.
  • Oligo Service — service-based oligo ordering.
  • Rapid HPLC Oligos — HPLC-purified oligos.
  • TruGrade DNA Oligos — a distinct purification/quality tier.
  • Mixed bases — oligos containing mixed-base positions.
  • Affinity Plus DNA Oligonucleotides — a premium DNA oligo line.
  • Normalized Oligos — oligos delivered at normalized concentration.

IDT states that >90% of standard desalted orders ship within 24 hours, and that oligos are quality checked by ESI-MS.

Custom RNA oligos

  • RNA Oligos — standard custom RNA synthesis.
  • Ultramer RNA Oligos — longer/higher-demand RNA oligos.
  • Affinity Plus RNA Oligonucleotides — premium RNA oligo line.

Custom GMP oligos

A separate category for oligos manufactured under GMP conditions, listed alongside the standard custom oligo lines.

Reagents

  • Nuclease Free Reagents
  • Nuclease Detection & Control

OligoCard

A dedicated ordering/delivery format listed under the oligo section.

Oligo modifications

IDT lists these modification groups for custom oligos:

Modification group What it covers
Attachment chemistry and linkers Chemistry for attaching oligos to surfaces or other molecules
Fluorophores and dark quenchers Fluorescent labels and quenchers for probe-based assays
Modified bases Non-standard bases incorporated into the oligo
Phosphorylation Phosphate group addition
Spacers Spacer units within the oligo
Click Chemistry Modifications Click-chemistry-compatible handles
Phosphorothioate bonds Backbone modification for stability

These modifications are selected during the custom oligo ordering process, so the available combinations depend on the oligo type (DNA, RNA, etc.) and synthesis constraints.

PCR, qPCR, and dPCR products

Beyond raw oligos, IDT offers assay-ready oligo products:

  • PrimeTime qPCR Probes and PrimeTime qPCR Custom Probe Based Assays
  • Affinity Plus qPCR Probes
  • PrimeTime LNA qPCR Probes
  • Molecular Beacons
  • MGB Eclipse Probes
  • GMP Primers & Probes
  • PrimeTime Pathogen Research Panels — flexible target selection, reliable results, easy ordering
  • PrimeTime Gene Expression Assays
  • PrimeTime Sexual Health Research Panels
  • rhAmp SNP Genotyping System and PACE SNP Genotyping Assays
  • Predesigned Gene Expression Assay Tool

Master mixes and reagents include PrimeTime Gene Expression Master Mix, PrimeTime One-Step 4X Broad-Range Master Mix, PrimeTime One-Step RT-qPCR Master Mix, rhAmp Genotyping Master Mix & Reporter Mixes, RNase H2 Enzyme, and oligo length standards.

How to choose

  • Standard primers/probes → DNA Oligos, with fluorophore/quencher modifications as needed.
  • Long or high-complexity constructs → Ultramer DNA or RNA Oligos.
  • High-throughput or pooled work → Oligo pools, HotPlates, or Normalized Oligos.
  • Higher purity requirements → Rapid HPLC or TruGrade lines.
  • Regulated or clinical-adjacent work → Custom GMP Oligos and GMP Primers & Probes.
  • Assay-ready qPCR/dPCR → PrimeTime probes and panels, or rhAmp/PACE genotyping assays.

For pricing and payment details, IDT's EU site links to a Payment Information page under Support. Exact prices, turnaround guarantees beyond the stated 24-hour shipping figure, and login requirements are not specified in the available site content, so confirm those on the product pages or with IDT support before ordering.