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What is Flownamics?
Flownamics is a bioprocess automation company that builds automated sampling systems and related lab hardware for biotechnology workflows. Its core idea is that instead of manually pulling samples from bioreactors, teams can use its Seg-Flow® systems to withdraw small, precise samples automatically and feed them to analyzers — reducing hands-on time and improving process consistency. The company says it has served this market for over 30 years and spans upstream small-scale R&D reactors through downstream production and purification.
What the product line covers
- Automated sampling: The Seg-Flow® family, including the Seg-Flow S3, uses patented Segmented Sampling Technology to take small, precise samples from bioreactors.
- Feeding: An automated system feeds from a single stock solution to as many as six bioreactors, managed by a compact, single-use syringe pump platform.
- Analytical integration: Flownamics products connect to third-party analysis platforms so samples can flow into online measurement rather than sitting in a queue.
- Sample handling and storage: A compact liquid handler, an automated sampler with an integrated fraction collector, and a Peltier cooling device with two temperature zones that holds sample racks down to 0°C.
- Cell counting and viability: An automated online system that provides cell viability and counting for up to eight bioreactors, including integration with the Vi-CELL BLU.
- Low-shear sampling: The Seg-Flow PS is described as low shear, which the company says suits cell and gene therapy applications.
- Sterile, cell-free sampling: A sampling probe for the Sartorius® Ambr® 250 Modular Vessel A allows withdrawal of sterile, cell-free samples.
Who it is for
The strongest fit is bioprocess teams running multiple bioreactors in parallel — process development groups, upstream and downstream labs, and cell and gene therapy groups — where sampling frequency and consistency matter more than a single measurement. If you run a handful of small-scale reactors and rely on manual sampling, the value is mostly in removing repetitive labor and tightening sampling timing. If you only need occasional offline samples, the automation is likely more infrastructure than the workflow requires.
A practical next step
List the analyzers you already trust — for example, an Agilent 1260 Infinity II Online LC or a Raman platform — and check whether Flownamics lists an integration for them. The company's own materials point to combinations with the Agilent Online LC and SegFlow S3 and SampleMod, and to enabling a Raman platform to interface with cell-containing and cell-free samples. If your analyzers are covered, ask for a virtual demo using your own reactor count and sampling schedule as the scenario; that will show whether the throughput and sample-handling capacity match your bench. For broader context on the vendors named here, see Agilent and Sartorius.
How does Flownamics' Seg-Flow automated sampling system work with bioreactors?
Flownamics' Seg-Flow automated sampling system connects bioreactors to analytical instruments through a patented segmented sampling approach. Rather than manually pulling a syringe and walking a sample to a lab, the system withdraws a small, precise volume from the reactor and transports it through tubing to downstream analyzers — keeping the sample stream separated and sterile along the way.
Key mechanics as described by the site
- Segmented Sampling Technology: the system isolates each sample in a minimum amount of time, which is what allows it to move small volumes reliably without diluting or cross-contaminating them.
- Sterile, cell-free sampling: a sampling probe option supports withdrawal of sterile, cell-free samples, which matters when the analyte is in the medium rather than inside the cells.
- Low-shear design: the Seg-Flow PS is described as low shear and suited to cell and gene therapy applications, where cells are fragile.
- Multi-reactor scale: one configuration feeds up to six bioreactors from a single stock solution via a compact single-use syringe pump platform, and an on-line viability/counting setup is described as covering up to eight bioreactors.
- Analytical integrations: the site lists integrations with Agilent's 1260 Infinity II Online LC, Sartorius Ambr 250 Modular vessels, Vi-CELL BLU viability counting, and Raman platforms — the sampler acts as the bridge between the reactor and whichever analyzer a team already uses.
- Sample handling: an integrated fraction collector, a Peltier cooling device with two temperature zones holding racks down to 0°C, and a compact liquid handler are offered for teams that need to preserve or archive samples rather than analyze them immediately.
What this means in practice
A process development group running a design-of-experiments campaign across several small reactors is the clearest fit: automated sampling removes the round-the-clock manual pulls that otherwise limit how many conditions can be tested and introduce timing variability between samples. A downstream or purification team can use the same platform where samples need consistent handling before analysis.
The trade-off is integration overhead. Seg-Flow is not a standalone analyzer — its value depends on pairing it with an LC, cell counter or Raman probe, so the real cost and complexity sit in that combined setup, and the choice of probe (cell-containing versus cell-free) has to match what the analyzer can accept.
Next step
Before requesting a demo, list the reactors you run and the analyzers you already own. Ask Flownamics which probe and integration matches that combination — the site's own examples (Ambr 250, 1260 Infinity II, Vi-CELL BLU, Raman) show the answer varies by setup. Comparing notes with peers at Sartorius or Agilent can also clarify whether the analyzer side of the chain is ready for automated feeding.
Can Flownamics sampling systems integrate with my existing analyzers like Agilent or Sartorius?
Yes, integration with third-party analyzers is a core part of what Flownamics offers. The company builds automated sampling systems designed to feed samples into analytical instruments rather than lock you into a closed ecosystem. Its site specifically names Agilent and Sartorius as integration partners.
Named integrations on the site
- Agilent: A combination of the Agilent 1260 Infinity II Online LC with the Flownamics SegFlow S3 and SampleMod, plus a performance evaluation of Flownamics sampling devices for the Agilent Online LC.
- Sartorius: A sampling probe for the Sartorius Ambr 250 Modular Vessel that withdraws sterile, cell-free samples.
- Raman platforms: An integration that lets a preferred Raman platform interface with cell-containing and cell-free samples from a bioreactor.
- Vi-CELL BLU: A fully automated on-line system providing cell viability and counting for up to eight bioreactors.
What this means in practice
If you already run an Agilent LC or a Sartorius Ambr system, the question is not whether Flownamics can connect, but which sampling device and interface match your workflow. The Seg-Flow S3 is the hub: it handles the sampling cycle, and the site notes a more graphical interface with intuitive monitoring and scheduling, so you can see cycle status and reagent levels at a glance. The Seg-Flow PS is described as low-shear and suited to cell and gene therapy applications.
How to decide
Map your analyzer first, then your sample type:
| Your setup | Relevant Flownamics option |
|---|---|
| Agilent 1260 Infinity II Online LC | SegFlow S3 + SampleMod |
| Sartorius Ambr 250 Modular | Dedicated sampling probe (sterile, cell-free) |
| Raman analyzer | Platform interface for cell-containing or cell-free samples |
| Vi-CELL BLU viability/counting | On-line system covering up to 8 bioreactors |
A practical next step is to contact Flownamics with your exact analyzer model and whether your samples are cell-containing or cell-free, since that distinction drives which probe or interface applies. The site also points to a webinar, "From Bioreactor to Analyzer," and offers a virtual demo. For broader context on the instruments themselves, see Agilent and Sartorius.
What types of bioprocess applications are Flownamics systems suitable for, from R&D to production?
Flownamics builds automated sampling and bioprocess automation hardware, and its own materials frame the range as spanning upstream small-scale R&D reactors through downstream production and purification. In practice, that means the systems are aimed at teams who need frequent, consistent samples pulled from bioreactors without tying up a person for every timepoint.
Where the systems fit
- Upstream cell culture and fermentation: The Seg-Flow line uses segmented sampling to deliver small, precise samples quickly. Flownamics states the low-shear design of the Seg-Flow PS suits cell and gene therapy work, where cells are fragile and viability matters.
- Small-scale R&D: The Ambr 250 Modular vessel sampling probe is described as withdrawing sterile, cell-free samples, which fits early process development on automated mini-bioreactor platforms.
- Downstream and purification: Flownamics explicitly lists downstream production and purification as an application area, so sampling is not limited to the bioreactor stage.
- Analytical integration: The company highlights linking sampling to analyzers — Agilent 1260 Infinity II Online LC with SegFlow S3 and SampleMod, Raman platforms (cell-containing and cell-free samples), and Vi-CELL BLU for viability and counting across up to eight bioreactors.
Scale and throughput
The feeding platform described on the page handles one stock solution feeding up to six bioreactors via a compact single-use syringe pump. Sampling automation is described for up to eight bioreactors in the viability-counting integration. Fraction collection is integrated into one sampler, and a Peltier device with two temperature zones holds sample racks down to 0°C — useful when samples wait in a queue before analysis.
How to decide
Match the system to your bottleneck. If your constraint is manual sampling labor across many small reactors, the multi-reactor sampling and feeding options matter most. If your constraint is sample stability, the cooled fraction collection and short sample path matter more. If your constraint is analytics, check that the sampler integrates with your existing LC, Raman or cell-counting platform before committing.
A practical next step: list your reactor count, sample frequency, and target analyzer, then ask Flownamics which configuration covers all three — the page offers a virtual demo and direct contact for exactly that conversation. You can review the product lines at Flownamics.
How does Flownamics ensure sterile, cell-free sampling for cell and gene therapy workflows?
Flownamics addresses sterility and cell removal through its Seg-Flow sampling systems, which use patented Segmented Sampling Technology to draw small, precise samples from bioreactors. The company states that low shear makes the Seg-Flow PS particularly suited to cell and gene therapy applications, and it offers a sampling probe for the Sartorius Ambr 250 Modular Vessel A that withdraws sterile, cell-free samples.
What the page supports
- Segmented sampling technology: Flownamics says its Seg-Flow systems use this patented approach to deliver a small, precise sample in minimal time.
- Sterile, cell-free withdrawal: A dedicated probe for the Sartorius Ambr 250 Modular Vessel A is described as allowing withdrawal of sterile, cell-free samples.
- Low-shear design: The Seg-Flow PS is described as low shear, which the company links to cell and gene therapy suitability.
- Integration with analytics: Flownamics lists integrations with Agilent 1260 Infinity II Online LC, Raman platforms, and Vi-CELL BLU for cell viability/counting across up to eight bioreactors.
What to verify for your workflow
Sterility and cell-free performance depend on your specific setup, so confirm these points with Flownamics or your own validation:
- Whether the sampling path is closed and how connections are sterilized.
- Whether the cell-free claim applies to your cell type, density and perfusion rate.
- How the system avoids clogging with high-density or aggregate-forming cultures.
- Whether the probe is compatible with your bioreactor model and vessel format.
Practical next step
If you are running cell and gene therapy processes, ask Flownamics for a method statement showing how the Seg-Flow PS or the Ambr 250 probe maintains sterility and removes cells in a workflow like yours, then request a virtual demo to see the sampling cycle and reagent monitoring in practice. For broader context on bioprocess sampling and automation, the Flownamics site is the primary source here.
What are the options for scheduling a demo or seeing Flownamics products in person?
Flownamics offers two practical ways to get hands-on with its bioprocess sampling and automation products: a scheduled virtual demo, and in-person appearances at industry events.
Virtual demo. The site's primary call to action is "Schedule A Virtual Demo," positioned as the way to "see the future of biotechnology for yourself." This suits teams that want a walkthrough of the Seg-Flow S3, the compact liquid handler, the integrated fraction collector, or the analytical integrations (for example, with Agilent's 1260 Infinity II Online LC or Vi-CELL BLU) without committing to travel. If your lab is comparing automated sampling options before a capital request, a virtual session is a low-friction first step; come with your reactor scale, sample volume and analysis cadence in hand so the demo addresses your workflow rather than a generic tour.
In-person. Flownamics maintains a "Where To See Flownamics Products" listing, which currently includes BPI East 2026 and a webinar dated Jan. 29, 2026, "From Bioreactor to Analyzer." Conference booths let you examine hardware such as the Peltier cooling device and sampling probes directly and talk to technical staff — useful if you need to judge physical footprint or integration with existing bioreactors.
Choosing between them
| Option | Best for | Trade-off |
|---|---|---|
| Virtual demo | Early evaluation, remote teams, specific integration questions | No physical inspection of hardware |
| Conference or webinar | Seeing multiple vendors at once, hardware close-up | Fixed dates and locations |
A sensible next step: book the virtual demo for your core evaluation, then check the events page to see whether a show lines up with your timeline. If you already run Sartorius Ambr 250 Modular vessels or a Raman platform, say so when scheduling — those integrations are specific enough that a tailored session saves time. You can start at Flownamics.
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